Vagus nerve stimulation reduces spreading depolarization burden and cortical infarct volume in a rat model of stroke

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Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke

BACKGROUND Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open. HYPOTHESIS This study tested the hypothesis that non-invasive VNS (nVNS), during transient middle cerebral artery occlusion (MCAO), protects the blood-brain barrier (BBB), leading to reduced infarct size in ischemic brain. ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2020

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0236444